High-dose thiotepa with autologous bone marrow rescue in recurrent malignant oligodendroglioma: A case report |
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Authors: | Ulla M. Saarinen Helena Pihko Anne Mäkipernaa |
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Affiliation: | (1) Children's Hospital, University of Helsinki, Helsinki, Finland;(2) Children's Hospital, Stenbäckinkatu 11, 00290 Helsinki, Finland |
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Abstract: | High-dose thiotepa with autologous bone marrow rescue is a new and promising treatment modality in several kinds of solid tumors. We used this regimen in a pediatric patient who had the third recurrence of his malignant oligodendroglioma of brain that developed during 8 in 1 chemotherapy. We achieved complete response after a total dose of 1125 mg/m2 of intravenous thiotepa. Good penetration into the CNS renders thiotepa potentially useful for chemosensitive brain tumors, and one course of high-dose thiotepa can be administered with acceptable toxicity by utilizing autologous bone marrow rescue. |
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Keywords: | autologous bone marrow transplantation glioma high grade oligodendroglioma thiotepa |
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