Family-based association studies of alpha-adrenergic receptor genes in chromosomal regions with linkage to bipolar affective disorder. |
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| Authors: | Rami Abou Jamra Johannes Schumacher Astrid Golla Carola Richter Andreas C J Otte Thomas G Schulze Stephanie Ohlraun Wolfgang Maier Marcella Rietschel Sven Cichon Peter Propping Markus M N?then |
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| Affiliation: | Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany. rami.aboujamra@uni-bonn.de |
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| Abstract: | Several lines of evidence suggest an involvement of the noradrenergic neurotransmitter system in the pathogenesis of bipolar affective disorder (BPAD). Three genes for alpha-adrenergic receptors (ADRA) are located in chromosomal regions that showed evidence for linkage: The alpha(1c)-adrenergic (ADRA-1C) receptor gene on 8p21, the alpha(2a)-adrenergic (ADRA-2A) receptor gene on 10q25, and the alpha(2c)-adrenergic (ADRA-2C) receptor on 4p16. In a BPAD sample of 120 parent-offspring triads, we genotyped a 492 Cys/Arg variant in exon 2 of the ADRA-1C gene, a -1291 G/C variant in the 5'UTR of the ADRA-2A gene, and a STR marker (adra2c1) in the 5'UTR of the ADRA-2C gene. Using the Transmission Disequilibrium Test (TDT), no significant differences in transmissions were observed for any of the three ADRA genes. |
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