外用0.1%他克莫司软膏配合窄谱UVB照射治疗寻常型斑块性银屑病的疗效观察 |
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引用本文: | 邵勇,于波,马刚,钟绮丽,程滨珠.外用0.1%他克莫司软膏配合窄谱UVB照射治疗寻常型斑块性银屑病的疗效观察[J].现代医学仪器与应用,2006(4). |
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作者姓名: | 邵勇 于波 马刚 钟绮丽 程滨珠 |
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作者单位: | 北京大学深圳医院皮肤科,北京大学深圳医院皮肤科,北京大学深圳医院皮肤科,北京大学深圳医院皮肤科,北京大学深圳医院皮肤科 广东,深圳518036,广东,深圳518036,广东,深圳518036,广东,深圳518036,广东,深圳518036 |
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摘 要: | 目的:观察他克莫司软膏配合窄谱中波紫外线(UVB)照射治疗寻常型斑块性银屑病的疗效及安全性。方法:将54例轻、中度斑块状银屑病患者随机分成3组,每组18例,治疗组采用外涂0.1%他克莫司软膏,每日2次,同时配合UVB照射治疗。治疗组Ⅰ每周照射2次,共8周,4周为1个疗程;治疗组Ⅱ每周照射1次,共2个疗程;对照组仅用UVB照射,每周照2次,共2个疗程。用PASI积分评价疗效,并观察不良反应。结果:经过1个疗程(4周)治疗后,治疗组Ⅰ有效率达到83.33%,显著高于对照组的有效率50%;经2疗程(8周)治疗,治疗组Ⅱ有效率达到88.89%,对照组的有效率为77.78%,两者相比疗效无显著差异。4例发生皮肤刺激反应,无1例光毒反应。结论:本疗法具有起效快、疗效高、安全性好的特点,可供临床应用。
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关 键 词: | 寻常型银屑病 他克莫司 窄谱UVB |
Observation of therapeutic effect of topical tacrolimus 0.1% ointment combing with narrow-band UVB phototherapy in the treatment of plaque psoriasis vulgaris |
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Authors: | Shao Yong Yu Bo Ma Gang Zhong Qi-li Cheng Bing-zhuFrom: |
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Institution: | Shao Yong,Yu Bo,Ma Gang,Zhong Qi-li,Cheng Bing-zhu.From:Department of Dermatology,Shenzhen Hospital of Peking University,Guangdong,Shenzhen 518036,China |
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Abstract: | Objective:Observing therapeutic effect and safety property of 0.1% tacrolimus ointment combining with narrow-band UVB phototherapy for plaque psoriasis vulgaris.Methods:54 mild and moderate patients of plaque psoriasis vulgaris were divided into 3 groups randomly.Two groups were treated topically with 0.1% tacrolimus ointment combining with narrow-band UVB phototherapy,0.1% Tacrolimus ointment was applied twice daily;and narrow-band UVB phototherapy was applied twice weekly to the first group of treatment for 8 weeks,once weekly to the second group of treatment for 8 weeks.The control group received narrow-band UVB phototherapy alone.The efficacy was assessed by the change of PASI score and adverse events were recorded.Results:After 1 courses of treatment(4 weeks),total effective rate of the first group was 83.33%,compared with(50%)in the control group,the efficacy was significant different.After 2 courses of treatment(8 weeks),total effective rate of the second group was 88.89%,compared with(77.78%)in the control group,the efficacy had no difference.Only 4 patients had skin stimulation during the treatment.The stimulation was desirable and bearable and had not influence to the treatment.No phototoxic reaction was reported.Conclusion:The treatment proved to be safe and highly effective,and worth to be recommended in clinical application. |
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Keywords: | Psoriasis Vulgaris Tacrolimus Narrow-band UVB Therapy |
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