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Mapping of RXRB to human chromosome 6p21. 3 |
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| Authors: | J. FITZGIBBON G. T. GILLETT K. J. WOODWARD J. M. BOYLE J. WOLFE S. POVEY |
| Affiliation: | Department of Genetics and Biometry, The Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE;MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE;Mothercare Clinical Genetics Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH;Cancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital and Holt Radium Institute, Manchester M20 9BX |
| Abstract: | Retinoid X Receptor beta (RXRB) is a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). We have confirmed the localization of RXRB to chromosome 6 and we have mapped the gene to chromosome 6p21. 3-p21.1 by PCR amplification of 5′ untranslated sequence in panels of rodent-human somatic cell hybrids and to 6p21.3 by fluorescent in situ hybridization. |
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