Spectrophotometric determination of cimetidine in pharmaceuticals and urine using batch and flow-injection methods |
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Authors: | Garcia Ma Soledad Albero Ma Isabel Sánchez-Pedreño Concepción Abuherba M S |
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Institution: | Department of Analytical Chemistry, Faculty of Chemistry, University of Murcia, 30071 Murcia, Spain. |
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Abstract: | Two sensitive and fast spectrophotometric methods using batch and flow-injection procedures for the determination of cimetidine (CMT) are proposed. The methods are based on the formation of a green complex between this drug and Cu(II) in acetic/acetate medium of pH 5.9. The calibration graphs resulting from measuring the absorbance at 330 nm are linear over the ranges 2.5 x 10(-6)-1.0 x 10(-3) and 5 x 10(-6)-2.0 x 10(-3) M with detection limits of 9.5 x 10(-7) and 2.1 x 10(-6) for batch and flow-injection methods, respectively. The methods are applied to the routine analysis of CMT in pharmaceuticals and human urine. |
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