急性冠状动脉综合征患者血清晚期氧化蛋白产物水平的测定意义

目的 探讨血清晚期氧化蛋白产物（AOPP）水平在急性冠状动脉综合征（ACS）中的意义及对预后的影响.方法 选择ACS患者共55例,其中不稳定型心绞痛（UAP）29例,急性心肌梗死（AMI）26例;正常对照组30例;采用分光光度计法检测所有入选者的血清AOPP浓度,并记录4周内所有患者的病情转归情况.结果 2组ACS患者AOPP水平均明显高于正常对照组（均P＜0.01）,AMI组AOPP水平高于UAP组（P＜0.05）;病情转归及预后差者AOPP水平相对高（P＜0.01）.结论 AOPP与ACS的发生有关,并且与病情的严重程度呈正相关,对病情转归有一定预测价值.

Clinical significance of serum concentration of advanced oxidation protein products in patients with acute coronary syndrome

Objective To investigate the clinical significance of serum concentration of advanced oxidation protein products (AOPP) in acute coronary syndrome(ACS)and its influence on prognosis of ACS.Methods The serum concentrations of AOPP were measured through spectrophotometer in 29 patients with unstable angina pectoris (UAP) and 26 patients with acute myocardial infarction (AMI) as well as 30 normal subjects.The outcomes of the treatment was recorded in all patients within 4 weeks.Results The serum levels of AOPP were significantly higher in AMI and UAP groups than those in control group (P<0.01),which were higher in AMI group than in UAP group (P<0.05).The improvement of the disease and the prognosis were poor in the patients with increased level of AOPP.Conclusion There is an obvious correlation between AOPP and ACS,and AOPP is positively correlated with severity of ACS.