| 碱性成纤维细胞生长因子在慢性间质性肾炎中的表达及意义 |
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| 引用本文： | 孙立,冯江敏,任青,马健飞,王力宁,周希静. 碱性成纤维细胞生长因子在慢性间质性肾炎中的表达及意义[J]. 中国实用内科杂志, 2005, 25(11): 1021-1022 |
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| 作者姓名： | 孙立 冯江敏 任青 马健飞 王力宁 周希静 |
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| 作者单位： | 中国医科大学附属第一医院肾内科,沈阳,110001 |
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| 摘 要： | 目的研究碱性成纤维细胞生长因子(bFGF)在慢性间质性肾炎(CIN)患者肾组织中的表达及意义。方法2001-022002-12对中国医科大学附属第一医院的30例慢性间质性肾炎患者及5例正常人采用免疫组织化学SP法检测肾组织中bFGF的表达,并采用图像分析技术测定bFGF阳性表达部分的平均灰度值、平均光密度值及其与整个视野面积的比值,所得数据进行统计学比较。结果慢性间质性肾炎患者肾间质中bFGF表达明显增强,其平均灰度值、平均光密度值及阳性表达面积较正常对照组差异有显著性。结论bFGF能够促进慢性间质性肾炎患者肾间质成纤维细胞及单核细胞增生,从而导致肾间质纤维化。
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| 关 键 词： | 慢性间质性肾炎 碱性成纤维细胞生长因子 纤维化 |
| 文章编号： | 1005-2194(2005)11-1021-02 |
| 修稿时间： | 2005-04-17 |
Expression of bFGF in chronic interstitial nephritis |
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| Sun Li,Feng Jiangmin,Ren Qing,et al.. Expression of bFGF in chronic interstitial nephritis[J]. Chinese Journal of Practical Internal Medicine, 2005, 25(11): 1021-1022 |
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| Authors: | Sun Li Feng Jiangmin Ren Qing et al. |
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| Affiliation: | Sun Li,Feng Jiangmin,Ren Qing,et al.Department of Nephrology,the First Affiliated Hospital of China Medical University,Shenyang 110001,China |
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| Abstract: | Objective To study the expression of basic fibroblast growth factor(bFGF)in the kidney tissues of chronic interstitial nephritis(CIN).Methods Expression of bFGF was assayed in 30 patients with CIN and 5 normal persons by SP method of immunohistochemical technique.The average gray value and average optical density of the bFGF positive parts and its ratio with the whole visual field had been measured with video analysis system.Results The expression of bFGF in the kidney tissues of CIN was significantly stronger than that in normal tissues.The average gray value,average optical density and the positive areas were significantly high compared with that of normal cases.Conclusion The bFGF can promote the proliferation of fibroblasts and monocytes in renal interstitial patients and lead to renal interstitial fibrosis in the end. |
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| Keywords: | Chronic interstitial nephritis Basic fibroblast growth factor Fibrosis |
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