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| 意向运动疗法对大鼠脑缺血再灌注损伤后NT-3及GAP-43表达的影响 | |
| 作者姓名： | Hou DR Shadike S Deng JF Liu JF Hu ZY Zhou J Zhou L Liu YX |
| 作者单位： | 1. 中南大学湘雅三医院 神经内科,湖南长沙,410013 2. 新疆医科大学附属中医医院脑病一科,新疆乌鲁木齐,830000 3. 中南大学湘雅三医院 中心实验室,湖南长沙,410013 |
| 基金项目： | 湖南省科技厅社会发展项目(2009SK3175;2010SK3110) |
| 摘 要： | 目的观察意向运动疗法对脑缺血再灌注损伤后缺血区脑组织NT-3及GAP-43蛋白表达的影响,探讨意向运动疗法对神经再生和修复的作用。方法运用线栓法制备大鼠大脑中动脉缺血再灌注损伤模型,随机分为大脑中动脉栓塞模型组(MCAO组)、饲养环境改变组(EM组)、意向运动疗法组(WM组),再灌注后3、7、15 d 3个时间点进行神经功能缺损评分、免疫组化法检测脑缺血区脑组织NT-3、GAP-43蛋白的表达。结果再灌注15 d时WM组神经功能缺损评分显著低于MCAO组及EM组(P<0.05);再灌注7、15 d时WM组的NT-3及GAP-43蛋白表达均显著高于MCAO组和EM组(P<0.05);EM组与MCAO组比较:NT-3及GAP-43蛋白的表达无明显差异(P>0.05);NT-3与GAP-43蛋白的表达变化呈正相关。结论意向运动疗法可促进脑缺血再灌注损伤大鼠缺血区脑组织NT-3、GAP-43蛋白的表达,可能与缺血损伤神经元的再生和修复有关。 |
| 关 键 词： | 意向运动 脑缺血再灌注损伤 神经营养因子-3 生长相关蛋白-43 |
Effect of willed movement therapy on the expression of neurotrophin 3 and growth-associated protein 43 in rats with cerebral ischemia reperfusion |
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| Hou DR,Shadike S,Deng JF,Liu JF,Hu ZY,Zhou J,Zhou L,Liu YX.Effect of willed movement therapy on the expression of neurotrophin 3 and growth-associated protein 43 in rats with cerebral ischemia reperfusion[J].Journal of Southern Medical University,2011,31(8):1401-1404. | |
| Authors: | Hou De-ren Shadike Shawuti Deng Jin-feng Liu Jian-feng Hu Zhong-yang Zhou Jun Zhou Li Liu Yuan-xin |
| Institution: | HOU De-ren1,Shadike·Shawuti2,DENG Jin-feng1,LIU Jian-feng1,HU Zhong-yang1,ZHOU Jun3,ZHOU Li3,LIU Yuan-xin2 1Department of Neurology,3Laboratory Center,Third Xiangya Hospital,Central South University,Changsha 410013,China,2Department of Encephalopathy,Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Urumqi 830000 |
| Abstract: | Objective To observe the effect of willed movement therapy on the expression of neurotrophin 3(NT-3) and growth associated protein 43(GAP-43) in rats with cerebral ischemia-reperfusion(IR) and investigate the neuroprotective mechanism of willed movement therapy in nerve regeneration and repair.Methods Cerebral IR model was established by middle cerebral artery occlusion(MCAO) in SD rats.The rats were randomly divided into MCAO group,environment modification group(EM group) and willed movement therapy group(... |
| Keywords: | willed movement therapy cerebral ischemia reperfusion neurotrophin 3 growth-associated protein 43 |
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