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| ITGA9基因rs189897与rs2212020及其单体型分子标志影响脑梗死发生 | |
| 引用本文： | 李湘民,李静,曾凤,易红.ITGA9基因rs189897与rs2212020及其单体型分子标志影响脑梗死发生[J].南方医科大学学报,2011,31(7):1142-1145. |
| 作者姓名： | 李湘民 李静 曾凤 易红 |
| 作者单位： | 中南大学湘雅医院急诊科;中南大学湘雅医院神经内科;中南大学湘雅医院卫生部肿瘤蛋白质组学重点实验室; |
| 基金项目： | 国家自然科学基金(30971033)~~ |
| 摘 要： | 摘要：目的研究ITGA9 基因rs189897 和rs2212020 位点及其单体型与脑梗死的关系。方法在脑梗死和正常对照样本 中，利用PCR-测序方法对rs189897和rs2212020位点进行基因分型，分型结果经SHEsis软件进行单个位点以及两个位点 构建的单体型与疾病关联性进行分析。结果rs189897和rs2212020位点等位基因频率、等位基因型频率在脑梗死患者和 正常对照人群中的分布存在统计学差异（P<0.05），同时还发现其A-C单体型为脑梗死发病的保护因子，拥有该单体型的 个体发生脑梗死的机率为不拥有该单体型个体的0.130倍。结论ITGA9基因rs189897、rs2212020位点与脑梗死发病密 切相关，其A-C单体型分子标志是脑梗死发生的保护因子。 |
| 关 键 词： | 脑梗死 ITGA9 单核苷酸多态性 单体型 |
Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction |
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| LI Xiang-min,LI ling,ZENG Feng,YI Hong.Association of ITGA9 gene rs189897 and rs2212020 genotypes and its haplotype with cerebral infarction[J].Journal of Southern Medical University,2011,31(7):1142-1145. | |
| Authors: | LI Xiang-min LI ling ZENG Feng YI Hong |
| Institution: | LI Xiang-min 1,LI Jing 2,ZENG Feng 1,YI Hong 3 1 Department of Emergency,2 Department of Neurology,3 Key Laboratory of Cancer Proteomics of State Ministry of Health,Xiangya Hospital,Central South University,Changsha 410008,China |
| Abstract: | Objective To study the association of ITGA9 gene rs189897 and rs2212020 polymorphisms and its haplotype with the occurrence of cerebral infarction(CI).Methods In the venous blood samples from 250 patients with cerebral infarction and 250 control samples,the genotypes of rs189897 and rs2212020 of ITGA9 gene were identified by PCR-sequencing.SHEsis software was used to analyze the association between the results of genotyping and the occurrence of CI.Results The cerebral infarction group and the control group... |
| Keywords: | cerebral infarction ITGA9 single nucleotide polymorphism haplotypes |
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