Toll-like receptor 4 gene polymorphism and giant cell arteritis susceptibility: a cumulative meta-analysis |
| |
Authors: | Alvarez-Rodriguez Lorena Muñoz Cacho Pedro Lopez-Hoyos Marcos Beares Ignacio Mata Cristina Calvo-Alen Jaime Villa Ignacio Martinez-Taboada Victor Manuel |
| |
Affiliation: | aDivision of Rheumatology, Hospital Universitario Marqués de Valdecilla-IFIMAV, Facultad de Medicina, Universidad de Cantabria, Santander, Spain;bDivision of Immunology, Hospital Universitario Marqués de Valdecilla-IFIMAV, Santander, Spain;cSection of Rheumatology, Hospital de Sierrallana-IFIMAV, Torrelavega, Cantabria, Spain;dGerencia Atención Primaria, Servicio Cántabro de Salud, Spain |
| |
Abstract: | ObjectiveToll-like receptor (TLR) 4 (+ 896 A/G) gene polymorphism has been reported to be associated with susceptibility to giant cell arteritis (GCA) with inconsistent results. To provide a more definitive conclusion, a cumulative meta-analysis of the association of TLR4 (+ 896 A/G) polymorphism with GCA susceptibility combining previous studies was performed.MethodsThe cumulative meta-analysis included 3 case–control studies which provided a total of 437 patients and 1023 controls. Meta-analysis was conducted by fitting random effects models and checked for heterogeneity and publication bias. Combined odds ratio (OR) and associated 95% confidence intervals (CI) were obtained by using a DerSimonian and Laird random effects model.ResultsThree studies, all from a South European ancestry, were identified through a literature search and included in this meta-analysis. The cumulative meta-analysis showed that the pooled random effects OR was non significant (OR: 1.46, 95% CI: 0.95–2.25; p = 0.082). There is some evidence suggestive of moderate–high heterogeneity between the three studies, I2 34.2% (95% CI: 0–55.2).ConclusionThis cumulative meta-analysis does not demonstrate an association of TLR4 (+ 896 A/G) gene polymorphism with susceptibility to GCA. Further studies using larger samples and in populations from different geographic origins are needed to determine the exact role of TLR4 gene polymorphisms in GCA. |
| |
Keywords: | Toll like receptor 4 Gene polymorphism Giant cell arteritis Meta-analysis |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|