抗感染药物引起不良反应报告的分析

目的分析抗感染药物引物药品不良反应（ＡＤＲ）的危害性。方法采用自愿报告方式收集１９９６－１９９８年６月抗感染药物引起的ＡＤＲ。结果１００８例抗感染药物引起ＡＤＲ中，涉及药品９８种，出现频次最多的是青霉素类，头孢菌素类、喹上起ＡＤＲ的分类以皮肤及其附件的损害最为多见，其次为全身性损害，消化系统损害，神经系统损害；对部分病例的调查显示单例治疗成本高达２．３４万元，持续时间最长达３００ｄ。结论ＡＤＲ的危

Analysis of ADR reports caused by anti-infectives

OBJECTIVE To analyse and determine the danger of adverse reaction of anti-infectives. METHODS The data come from PLA Center for ADR monitoring during 1996-1998 by spontaneous reporting. RESULTS One thousand and eight cases of ADR associated with 98 anti-infectives mostly involved use of penicillins, cephalosporins and quinolones. san lesions accounted for 59.23% of all the reported ADRs, and then were the lesions of the whole body, digestive system and nervous system. CONCLUSIONS It is important to strengthen the ADR monitoring for reducing the denger of ADR and increasing the level of antimicuboial rational utilisation.