大豆异黄酮对代谢综合征患者干预效果的Meta分析

目的　研究大豆异黄酮对代谢综合征患者多项指标的影响。方法　检索PubMed、中国知网、中国生物医学文献数据库、万方医学数据库和重庆维普数据库，搜索有关大豆异黄酮与代谢综合征的随机对照试验。采用RevMan5.3软件进行Meta分析。结果　纳入9项研究，有395例代谢综合征患者参与。Meta分析结果显示大豆异黄酮干预能提高患者高密度脂蛋白胆固醇水平［SMD=0.32，95%CI（0.16，0.48），P<0.0001］，降低腰围［SMD=-0.56，95%CI（-1.07，-0.04），P=0.0200］、甘油三酯［SMD=-0.56，95%CI（-0.94，-0.18），P=0.0040］、总胆固醇［SMD=-3.39，95%CI（-4.76，-2.01），P＜0.0001］、低密度脂蛋白胆固醇［SMD=-1.42，95%CI（-2.23，-0.61），P=0.0006］、收缩压［SMD=-0.33，95%CI (-0.51, -0.15)，P=0.0004］、舒张压［SMD=-0.28，95%CI (-0.46, -0.10)，P=0.0030］及空腹血糖水平［SMD=-1.12，95%CI（-2.02，-0.23），P=0.0100］。结论　大豆异黄酮能够有效改善代谢综合症患者多项指标。

Effect of soybean isoflavone intake on patients with metabolic syndrome: a meta-analysis

Objective　To study the effects of soybean isoflavone on patients with metabolic syndrome (MS). [WTHZ]Methods　Randomized controlled trials (RCTs) related to soybean isoflavone and metabolic syndrome were searched in PubMed, CNKI, CBM, VIP and WanFang Data. RevMan5.3 software was used in the meta-analysis. [WTHZ]Results　395 MS patients from 9 RCTs were included. The results of mate-analysis showed that soybean isoflavone intervention could improve MS patients with high-density lipoprotein cholesterol levels ［SMD=0.32, 95%CI (0.16, 0.48), P<0.0001］, reduce waist circumference ［SMD=-0.56, 95%CI (-1.07, -0.04), P=0.0200］, triglyceride ［SMD=-0.56, 95%CI (-0.94, -0.18), P=0.0040］, total cholesterol level ［SMD=-3.39, 95%CI (-4.76, -2.01), P<0.0001］, low-density lipoprotein cholesterol level ［SMD=-1.42, 95%CI (-2.23, -0.61), P=0.0006］, systolic blood pressure ［SMD=-0.33, 95%CI (-0.51, -0.15), P=0.0004］, diastolic blood pressure ［SMD=-0.28, 95%CI (-0.46, -0.10), P=0.0030］ and fasting plasma glucose level ［SMD=-1.12, 95%CI (-2.02, -0.23), P=0.0100］. [WTHZ]Conclusion　Soybean isoflavone can effectively improve many indexes of patients with metabolic syndrome.