缺血性脑血管病与炎性免疫因子

免疫炎性反应在脑缺血后损伤中起重要作用,脑缺血的炎性免疫损伤是一个复杂的病理过程,免疫炎性因子是调节损伤过程免疫反应的关键因子。在炎性反应发生之前,可有细胞因子介导、参与免疫调节和趋化作用,促进白细胞黏附于血管内皮细胞,引起并加重脑缺血损伤,细胞因子产生后进一步诱导黏附分子和趋化因子的表达,促使炎性免疫细胞浸润到损伤组织,炎性免疫细胞及其产生的细胞因子又相互诱导激活,进一步加重组织损伤。

Ischemic Cerebral Vascular Disease and Inflammatory Immune Factors

The inflammatory immune response plays an important part in cerebral ischemic injury,of which the inflammatory immune injury is a complex pathological course.Inflammatory immune factors are the primary factors regulating inflammatory immune response during the injury processes.Before inflammatory reaction,many cytokines can mediate or participate immunoregulation and chemotaxis,which can promote adhesion of white blood cells to vascular endothelial cells,and aggravate cerebral ischemia injury.The production of cytokines can further induce the expression of adhesion molecular and chemotatic factor,which promote invasion of inflammatory immune cells to injuried tissue.Inflammatory immune cells and their cytokines can mutual induction and activation,which can further aggravate tissue injury.