Synthesis and evaluation of curcumin analogues as cytotoxic agents |
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Authors: | Ahmed A Fadda Farid A Badria Khaled M El-Attar |
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Institution: | (1) Chemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt;(2) Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt |
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Abstract: | Seventeen curcumin analogues were prepared and evaluated for in vitro and in vivo cytotoxicity against an Ehrlich ascites
carcinoma (EAC). In vitro results revealed that compounds 10, 7, and 12 were the most potent analogues against EAC respectively. However, in vivo evaluation of compound 10 proved its capability to normalize the blood picture compared with 5-fluorouracil, a well-known anticancer drug. |
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