角质细胞生长因子及E-钙黏蛋白在胰腺癌组织中的表达及其意义

目的 研究角质细胞生长因子(KGF)及E-钙黏蛋白(E-cadherin)在胰腺癌组织中的表达及其临床意义.方法 应用免疫组织化学SP法检测45例胰腺癌组织、22例癌旁正常胰腺组织中KGF及E-cadherin的表达,并结合临床病理资料进行分析.结果 KGF在胰腺癌组织阳性表达率为77.8%(35/45),比相应的癌旁正常胰腺组织表达明显增高,且与癌组织分化程度及临床分期相关(P值均＜0.05);E-cadherin在胰腺癌组织比相应的癌旁正常胰腺组织表达减低,高表达率为35.6%(16/45),且与癌组织分化程度、淋巴结转移及临床分期密切相关(分别为P＜0.05,P＜0.05,P＜0.01);在胰腺癌组织中,KGF与E-cadherin表达呈负相关(P＜0.01).结论 KGF与E-cadherin有望作为胰腺癌的增生、分化、侵袭以及转移的重要生物学指标.

Expression of KGF and E-cadherin in pancreatic adenocarcinoma and their clinical significance

Objective To study the expression of KGF and E-cadherin in pancreatic adenocarcinoma and their clinical significance.Methods The expression of KGF and E-cadherin in 45specimens of paraffin-embeded pancreatic adenocarcinoma and 22 normal pancreas amund tumors was detected by using immunohistochemistry staining(sP)and compared with clinicopathological data.Results The increased expression of KGF in pancreatic adenocarcinoma was significantly higher than that in normal pancreas,the positive rate of KGF was 77.8%(35/45),and there was a relationship between hish KGF expression and the differentiation of carcinoma and the clinical stages(P＜0.05,0.05,respectively).The decreased expression of E-cadherin in pancreatic adenocarcinoma was lower than that in normal pancreas.The higher rate of expression was 35.6%(16/45),and a significant relationship was observed between low Ecadherin expression and the differentiation of carcinoma.the metastasis of lymph nodes and the clinical stages (P＜0.05,0.05,0.01,respectively).The expression between KGF and E-cadherin had a significant relation in pancreatic adenoeareinoma (P＜0.01).Conclusion The level of KGF and E-cadherin may be a sensitive predictor of proliferation,differentiation,invasion and metastasis of pancreatic adenocarcinoma.