HLA genes in Lamas Peruvian-Amazonian Amerindians |
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Authors: | Moscoso Juan Seclen Segundo Serrano-Vela Juan I Villena A Martinez-Laso Jorge Zamora Jorge Moreno Almudena Ira-Cachafeiro Juan Arnaiz-Villena Antonio |
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Affiliation: | Departments of Inmunologia and Medicina Interna, Hospital 12 Octubre, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain. |
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Abstract: | The Lamas Amerindians are the Chancas descents who established before 1532 a.d. (Spanish conquest) at Lamas City, Wayku quarter in a Peruvian-Amazonian province (San Martin). The Lamas HLA profile shows significant differences with other Amerindians HLA profile, i.e.: (a) a higher number of newly found haplotypes compared to other studied Amerindian populations, particularly HLA-A*02-B*48-DRB1*0403-DQB1*0302, A*02-B*48-DRB1*0804-DQB1*0402 and A*02-B*40-DRB1*0407-DQB1*0302; (b) a relative high frequency of HLA-DRB1*0901 (a high frequency southern Asian allele) and HLA-B*48 (a Na-Dene, Siberian and Eskimo allele); both alleles are also found frequently in Quechuas and Aymaras, but not in many other (particularly Meso American) Amerindians and (c) correspondence and neighbor-joining dendrogram analyses show that Lamas (Chancas) may have an origin close to Amazonian Indians that later reached the Andean altiplano. |
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