不同剂量的阿托伐他汀对不稳定心绞痛患者冠脉炎症的影响

目的研究阿托伐他汀对不稳定型心绞痛患者冠脉炎症的影响,不同剂量阿托伐他汀的作用是否不同。方法将不稳定型心绞痛患者共232例,分为服用阿托伐他汀10mg/d、20mg/d、40mg/d和对照组共4组,分别测定治疗前和治疗3个月、6个月血中CRP和IL-6的浓度变化,评估阿托伐他汀对不稳定型心绞痛患者冠脉炎症的作用。结果阿托伐他汀各治疗组与对照组相比,均能明显降低CRP,其中大剂量阿托伐他汀降低CRP更明显,与其他各组相比差异有统计学意义;阿托伐他汀对IL-6的影响不大。结论早期大剂量使用阿托伐他汀能有效控制不稳定型心绞痛患者的冠脉炎症,控制程度与阿托伐他汀的使用剂量成正比。

Effect of different-dose atorvastatins on inflammation of coronary artery in patients with unstable angina

Objective To study the effect of atorvastatin on inflammation of coronary artery in patients with unstable angina, to assess if different-dose atorvastatin result in different ontcome. Methods Patients with unstable angina were randomized to atorvastatin 10mg/d or 20mg/d or 40mg/d or controls. Then mensurated the serum concentrotion of CRP and IL-6 on the subjects in different groups, to assess the effect of atorvastatin on inflammation in patients with unstable angina. Results Comparing all group of taking atorvastatin with controls, we found that atorvastatin can reduce CRP markedly, especially with high-dose atorvastatin, but has little effect on IL-6. Conclusion Early high-dose atorvastatin therapy can markedly decline inflammation in patient with unstable angina.