慢性肾病患者血清HA和血浆VEGF检测的临床意义

目的：探讨了慢性肾病患者血清透明质酸（HA）和血浆血管内皮生长因子（VEGF）水平。方法：应用放免法和酶联双抗体法测定38例慢性肾病患者血清HA和血浆VEGF的含量，并以35名正常人作比较。结果：慢性肾病患者血清HA和血浆VEGF含量显著地高于正常人组（P〈0．01），经治疗6个月后与正常人比较仍有差异（P〈0．05）。结论：慢性肾病的发生、发展与HA和VEGF水平密切相关。

Clinical Significance of Determination of Changes of Serum Hyaluronic Acid (HA) and Plasma Vascular Endothelial Growth Factor (VEGF) Contents After Treatment in Patients with Chronic Nephropathy

Objective To investigate the changes of serum HA and plasma VEGF levels after treatment in patients with chronic nephropathy.Methods Serum HA contents were determined with RIA and plasma VEGF with ELISA in 38 patients with chronic nephropathy both before and after treatment as well as in 35 controls.Results Before treatment the serum HA and plasma VEGF levels were significantly higher in the patients than those in the controls(P<0.01).After 6 months of treatment,the levels remained significantly higher(P<0.05).Conclusion Development of chronic nephropathy was closely related to the serum HA and plasma VEGF levels.