Glucose as a Potential Key to Fuel Inflammation in Rheumatoid Arthritis |
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Authors: | Kayo Masuko |
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Affiliation: | 1.Department of Internal Medicine, Akasaka Sanno Medical Center, Tokyo 107-8402, Japan; Tel.: +81-3-6230-3701; Fax: +81-3-6230-3702;2.Clinical Research Center, International University of Health and Welfare, Tokyo 107-8402, Japan |
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Abstract: | Glucose is the most important source of energy and homeostasis. Recent investigations are clarifying that glucose metabolism might be altered in rheumatoid arthritis (RA), which would play a role in the inflammatory phenotype of rheumatoid synovial fibroblasts. It may also play a role in a variety of autoimmune diseases’ pathophysiology by modulating immune responses and modifying autoantigen expressions. The research into glucose and its metabolism could lead to a better understanding of how carbohydrates contribute to the occurrence and duration of RA and other autoimmune diseases. |
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Keywords: | rheumatoid arthritis glucose autoimmunity |
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