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Glucose as a Potential Key to Fuel Inflammation in Rheumatoid Arthritis
Authors:Kayo Masuko
Affiliation:1.Department of Internal Medicine, Akasaka Sanno Medical Center, Tokyo 107-8402, Japan; Tel.: +81-3-6230-3701; Fax: +81-3-6230-3702;2.Clinical Research Center, International University of Health and Welfare, Tokyo 107-8402, Japan
Abstract:Glucose is the most important source of energy and homeostasis. Recent investigations are clarifying that glucose metabolism might be altered in rheumatoid arthritis (RA), which would play a role in the inflammatory phenotype of rheumatoid synovial fibroblasts. It may also play a role in a variety of autoimmune diseases’ pathophysiology by modulating immune responses and modifying autoantigen expressions. The research into glucose and its metabolism could lead to a better understanding of how carbohydrates contribute to the occurrence and duration of RA and other autoimmune diseases.
Keywords:rheumatoid arthritis   glucose   autoimmunity
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