含羟基磷灰石生物陶瓷应用于口腔种植的动物实验研究

目的　探讨含羟基磷灰石生物陶瓷在口腔种植的效果与优点。方法　首先将含羟基磷灰石生物陶瓷进行毒性试验 ,包括全身毒性试验、皮肤刺激试验、溶血试验、Ames试验及细胞毒性试验。分纯钛试验 (空白对照 )组 ,单纯HA组及含HAZrO组 ,选健康杂种犬 8只 ,在双侧下颌骨体形成即约 15mm× 2 0mm的骨颌损 ,分别植入 3组材料 ,分层缝合关闭切口。结果　早期肉眼可见实验组与对照组材料与软组织结合良好 ,所有实验动物伤口均无破溃与分泌物 ,无HA颗粒及含HA的ZrO2 复合陶瓷及纯钛逸出 ,切口Ⅰ期愈合。结论　含HA生物陶瓷复合材料可用于颌骨缺损及其他植入手术中。

Experimental Study on the Application of Hydroxyapatite - contain Bioceramic in Denture Implantation

Objective To investigate the effects of hydroxyapatite (HA)-contain bioceramic in denture implantation. Methods First, HA-contain bioceramic toxic tests including generalized toxic test, skin stimulation test, hemolytic test, Ames test and cytotoxic test were carried out. 8 canines were divided into titanium group (control group), HA group and HA-contain bioceramic group. The three materials were implanted in 15mm×20mm defects created in both sides of the mandible body. Results In earlier period, the three materials and soft tissues healing well; no ulceration and effusion, no HA, HA-contain bioceramic or titanium leakage in the three groups. Conclusion HA-contain bioceramic can be used in implanting operation for mandible defects or other diseases.