| 基质金属蛋白酶-9和上皮型钙粘附蛋白在非小细胞肺癌中的表达及其预后意义 |
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| 引用本文： | 霍建民,徐晓辉. 基质金属蛋白酶-9和上皮型钙粘附蛋白在非小细胞肺癌中的表达及其预后意义[J]. 中国实用内科杂志, 2004, 24(7): 410-411 |
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| 作者姓名： | 霍建民 徐晓辉 |
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| 作者单位： | 哈尔滨医科大学第一临床医学院呼吸内科,150001 |
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| 摘 要： | 目的 探讨基质金属蛋白酶 9(MMP 9)和上皮型钙粘附蛋白 (E cadherin ,E cad)在非小细胞肺癌(NSCLC)中的表达及临床意义。方法 1995～ 1997年采用免疫组织化学SP法检测MMP 9和E cad在哈尔滨医科大学第一医院住院的 6 2例NSCLC患者组织和 18例正常肺组织中的表达。结果 NSCLC组织中的MMP 9的阳性表达率和E cad的异常表达率与肿瘤病理分级、TNM分期和淋巴结转移有密切关系 (P <0 0 5 )。MMP 9、E cad的表达水平与NSCLC患者的预后显著相关。结论 MMP 9、E cad可作为判断NSCLC恶性程度及预后的指标。
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| 关 键 词： | 基质金属蛋白酶9 上皮型钙粘附蛋白 非小细胞肺癌 |
| 文章编号： | 1005-2194(2004)07-0410-02 |
| 修稿时间： | 2003-12-12 |
Expression of MMP-9 and E-cadherin in NSCLC and their prognostic value |
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| Huo Jianmin,Xu Xiaohui. Expression of MMP-9 and E-cadherin in NSCLC and their prognostic value[J]. Chinese Journal of Practical Internal Medicine, 2004, 24(7): 410-411 |
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| Authors: | Huo Jianmin Xu Xiaohui |
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| Affiliation: | Huo Jianmin,Xu Xiaohui.Department of Pulmonary Medicine,the First Hospital of Harbin Medical University,Harbin 150001,China |
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| Abstract: | Objective To study the clinical significance of the expression of matrix metalloproteinase-9(MMP-9) and E-cadherin(E-cad) in patients with non-small cell lung cancer (NSCLC).Methods Immunohistochemical method (SP) was used to detect the expression of the MMP-9 and E-cad in 62 NSCLC tissues and 18 normal lung tissues.Results The positive expression rate of MMP-9 and the abnormal expression rate of E-cad in NSCLC were closely related to the TNM stages,pathological grades and lymph node involvement (P<0.05).The levels of MMP-9 and E-cad expression were associated with unfavorable prognosis.Conclusion MMP-9 and E-cad could be used as markers of malignant potential and prognosis factor of NSCLC. |
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| Keywords: | Matrix metalloproteinase-9 E-cadherin Non-small cell lung cancer |
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