Oral sumatriptan in the acute treatment of migraine and migraine recurrence in general practice |
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Authors: | Scott RJ; Aitchison WR; Barker PR; McLaren GI |
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Institution: | General Practice Units in Edinburgh, Renfrewshire and Great Missenden, UK; Corresponding author at: The Surgery, 60 Leith Walk, Edinburgh EH6 5HB, UK |
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Abstract: | We investigated the efficacy, safety and tolerability compared with placebo
of a second dose of oral sumatriptan 100 mg in 1349 general practice
patients who had already treated a moderate or severe migraine headache
with 100 mg sumatriptan 4 h earlier. Headache was relieved by the first
sumatriptan dose in about 70% of patients, but the second dose did not
produce significantly more relief than placebo, either in nonresponders or
in the group as a whole, nor did it reduce other symptoms (photophobia,
nausea, vomiting, etc,) at 8 h, or influence the incidence of headache
recurrence. The drug was well-tolerated, and a further single dose was
effective in treating recurrence after initial relief. A single 100 mg dose
of sumatriptan is an effective acute treatment for migraine. A second dose
should be reserved for treating headache recurrence.
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