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Granulocyte Colony Stimulating Factor and MT1-MMP Involved in Development of Atherosclerosis in Apolipoprotein E-Deficient Mice |
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| Authors: | Su-zhen GUO res J Espinoza Christian A Espinoza Terence M Doherty Xiao WANG Human Pathology Center / Capital Medical University Beijing China The Atherosclerosis Research Center Division of Cardiology / The Burns Allen Research Institute Cedars-Sinai Medical Center David Geffen School of Medicine at UCLA Los Angeles California USA |
| Institution: | Su-zhen GUO1,Andres J. Espinoza2,Christian A. Espinoza2,Terence M. Doherty2,Xiao WANG2 1 Human Pathology Center / Capital Medical University,Beijing 100069,China 2 The Atherosclerosis Research Center and Division of Cardiology / The Burns and Allen Research Institute,Cedars-Sinai Medical Center and David Geffen School of Medicine at UCLA,Los Angeles,California USA 90048 |
| Abstract: | Objectives Genetic deficiency of macrophage colony stimulating factor (M-CSF) in atherosclerosis-prone (apoE-/-) mice markedly reduces formation of atheroma. But Little is known about the potential effects of other colony stimulating factors(CSF),such as granulocyte CSF(G-CSF),on atherosclerosis. This study tested the hypothesis that G-CSF would be involved in development of atherosclerotic plaque. Methods apoE-/-mice fed with a Western-style diet (0.15% cholesterol) were injected subcutaneously with recomb... |
| Keywords: | atherosclerosis G-CSF apolipoprotein E serum cholesterol MMPs |
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