铜绿假单胞菌医院感染危险因素及耐药性分析

目的 了解铜绿假单胞菌发生医院感染的各种危险因素及其耐药性,规范院内感染控制措施,降低医院感染率,指导临床合理用药、提高医疗质量、改善患者预后.方法 回顾性调查2009年1月至2011年12月我院临床分离的铜绿假单胞菌152株,分析标本来源及其感染危险因素和耐药性.结果 铜绿假单胞菌感染主要来源呼吸道,占57.2%,高度危险因素为:住院时间长、年龄>60岁、严重基础疾病、机械通气时间、长期应用抗生素、深静脉导管;在10种抗生素中亚胺培南、哌拉西林/他唑巴坦、阿米卡星敏感性高,敏感度分别为90.7%,79.2%,70.0%.结论 规范院内感染控制措施,降低医院感染率,根据临床药敏结果合理选择抗菌素进行治疗,防止耐药菌株的产生和播散.

Pseudomonas aeruginosa nosocomial infection risk factors and drug resistance analysis

Objective Understanding of Pseudomonas aeruginosa nosocomial infection risk factors and drug resistance of nosocomial infection control measures,standardize,reducing the rate of hospital infection,guide clinical rational drug use,improve the quality of medical care,improve patient prognosis Methods A retrospective survey of 2009 January to 2011 December in our hospital clinical isolates of Pseudomonas aeruginosa strain 152,analysis of the specimen sources and risk factors for infection and drug resistance.Results Pseudomonas aeruginosa infection on major source of respiratory tract,accounted for 57.2%,high risk factors:the duration of hospitalization,age >60 years,severe underlying disease,duration of mechanical ventilation,long-term application of antibiotics,central venous catheter;in 10 kinds of antibiotic imipenem,piperacillin/tazobactam,Amikacin sensitivity,sensitivity is respectively 90.7%,79.2%,70%.Conclusion Specification for hospital infection control measures,reducing the rate of hospital infection,according to the clinical drug sensitivity results reasonable choice of antibiotics for therapy,prevent the emergence and spread of drug-resistant strains.