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| 小儿消咳片中白屈菜红碱的含量测定 | |
| 引用本文： | 赵磊,刘嘉乐,李岩,孙艳涛. 小儿消咳片中白屈菜红碱的含量测定[J]. 医药导报, 2012, 31(1): 70-72. DOI: 10.3870/yydb.2012.01.027 |
| 作者姓名： | 赵磊 刘嘉乐 李岩 孙艳涛 |
| 作者单位： | 1. 吉林省四平市食品药品检验所,136000 2. 吉林省神经精神病医院,四平,136000 3. 吉林师范大学化学学院,四平136000;江苏大学化学化工学院,镇江212013;吉林师范大学环境友好材料制备与应用省部共建教育部重点实验室,四平136000 |
| 基金项目： | 吉林省教育厅“十二五”科学技术项目(2011189);吉林师范大学硕、博士启动资金项目(2005089);四平市科技项目(2009020) |
| 摘 要： | 目的 建立高效液相色谱(HPLC)法测定小儿消咳片中白屈菜红碱的含量测定方法. 方法采用HPLC法,色谱柱:Zorbax SB C18(250 mm×4.6 mm,5 μm),流动相:乙腈 1%三乙胺溶液(磷酸调pH为3.0)(25:75),检测波长:269 nm;流速1.0 mL.min-1,进样量10 μL. 结果 白屈菜红碱在8.25～825.00 μg.mL-1范围内线性关系良好(r＝0.999 8),平均加样回收率为96.80%,RSD为1.11%(n＝6). 结论 该方法简便快捷,准确,重复性好,灵敏度高,可用于小儿消咳片的质量控制. |
| 关 键 词： | 小儿消咳片 白屈菜红碱 色谱法,高效液相 含量测定 |
| 收稿时间： | 2011-04-22 |
| 修稿时间： | 2011-06-10 |
Content Determination of Toddaline in Xiao'er Xiaoke Tablets by HPLC |
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| ZHAO Lei,LIU Jia-le,LI Yan,SUN Yan-tao. Content Determination of Toddaline in Xiao'er Xiaoke Tablets by HPLC[J]. Herald of Medicine, 2012, 31(1): 70-72. DOI: 10.3870/yydb.2012.01.027 | |
| Authors: | ZHAO Lei LIU Jia-le LI Yan SUN Yan-tao |
| Affiliation: | 3,4,5(1.Institute for Food and Drug Control of Siping City,Jilin Province,136000,China;2.Mental Derangement Hospital of Jilin Province,Siping 136000,China;3.College of Chemistry,Jilin Normal University,Siping 136000,China;4.Institute of Chemistry and Chemical Engineering,Jiangsu University,Zhenjiang 212013,China;5.Key Laboratory of Preparation and Applications of Environmental Friendly Materials,Ministry of Education China,Jilin Normal University,Siping 136000,China) |
| Abstract: | Objective To establish a HPLC method for determination of toddaline in xiao’er xiaoke bablets.Methods Zorbax SB-C18(250 mm×4.6 mm,5 μm)was used.The mobile phase was acetonitrile-1% triethylamine(pH 3.0 adjusted by phosphoric acid)(22:78).The flow rate was 1.0 mL·min-1 and detection wavelength was set at 269 nm.Results The linear range of gastrodin was 8.25-825.00 μg·mL-1(r = 0.999 8).The average recovery was 96.80%(n=6)(RSD=1.11%).Conclusion This method is simple,accurate and reproductive,which can be used for the quality control of xiao’er xiaoke bablets. |
| Keywords: | Xiao’er xiaoke bablets Toddaline HPLC Content determination |
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