牛磺酸治疗高同型半胱氨酸脑梗死患者动脉粥样硬化的临床观察

Objective To investigate the therapeutic effect of taurine on atherosclerosis in patients with hyperhomocysteinemia (Hhcy)-induced cerebral infarction (CI). Methods Forty patients with CI induced by Hhcy were randomizod into two equal groups to receive taurine injections or folacin plus vitamin B12 treatment for 6 months. Color Doppler ultrasound was performed to examine the intima-media thickness (IMT) and the plaques in the carotid artery before and after the treatment. Blood samples were obtained from the patients to determine the changes in plasma homocysteic acid (Hcy) level using high-pressure liquid chromatography. Results Both taurine injections and folacin plus vitamin BI2 treatment for 6 months resulted in a significant reduction in the IMT of the carotid artery (P<0.05), but taurine caused a significantly greater reduction (0.551 mm vs 0.372 mm, P<0.05). Taurine also showed a better effect than folacin plus vitamin B12 in decreasing the number of atherosclcrotic plaques (P<0.05). Taurine treatment significantly decreased the plasma Hcy level as compared with the level before treatment (19.316±2.240 μmol/L v, 29.832±7.750 μmol/L, P<0.05). Conclusions Taurine has better therapeutic effect than folacin plus vitamine B12 oil atherosclerosis and helps control plasma Hcy level in patients with Hhcy-induced CI.

Effect of taurine on atherosclerosis in patients with cerebral infarction induced by hyperhomocysteinemia