急性脑梗死患者血清胱抑素C与同型半胱氨酸及颈动脉内膜中层厚度的相关性探讨

目的探讨急性脑梗死(ACI)患者血清胱抑素C(Cys C)水平与血同型半胱氨酸(Hcy)以及颈动脉粥样硬化(CAA)的相关性。方法选择120例脑梗死患者为观察组,同期住院非脑血管疾病患者60例为对照组。检测并比较2组血清Cys C、三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDLC)、空腹血糖(FPG)、Hcy水平,以及应用彩色多普勒超声检测其颈动脉内膜中层厚度(IMT)。结果观察组和对照组血清Cys C水平分别为(1.36±0.24)mg/L和(1.03±0.13)mg/L,2组比较差异有统计学意义(P<0.01);2组TG、TC、LDL-C、HDL-C、FPG、Hey水平及颈动脉IMT比较差异亦均有统计学意义(P<0.01)。血清Cys C水平与TC、TG、HDL-C、LDL-C、FPG均无相关性(r=0.076、-0.158、-0.040、0.012、-0.176,P均>0.05),而与血Hey及颈动脉IMT均呈显著正相关(r=0.871、0.819,P均<0.01)。结论高Cys C血症是脑梗死重要危险因素,与血Hey呈正相关,且与颈动脉粥样硬化的形成密切相关。

Relationship of serum Cys-C,homocysteine level and intima-media thickness in carotid artery atherosclerosis with acute cerebral infarction

Objective To investigate the correlation of serum cystatin C （ Cys-C）, the level of plasma homocysteine （Hcy） and carotid atherosclerosis （CAA） in acute cerebral infarction （ACI） patients： Methods One hundred and twenty cases of cerebral infarction patients were enrolled as observation group, in the same period, 60 cases of non-cerebrovascular disease patients were enrolled as a control group. The serum Cys-C, three glycerol （TG）, cholesterol （TC）, low density lipo- protein cholesterol （ LDL-C）, high density lipoprotein cholesterol （ HDL-C）, fasting blood glucose （FPG）, Hcy levels of the 2 groups were detected and compared, as well as used the color Doppler ultrasound to detect the carotid artery intima-media thick- ness （IMT）. Results The observation group and the control group of serum Cys-C were （1.36±0.24） mg/L and （1.03 ±O. 13） mg/L, there was significant difference between the 2 groups （ P 〈 0. O1 ） ; TG, TC, LDL-C, HDL-C, FPG, Hcy level and carotid artery IMT were significant different between the 2 groups （ P 〈 0.01 ）. Serum Cys-C level and TC, TG, HDL-C, LDL-C, FPG are not correlated （ r = 0. 076, - 0. 158, - O. 040, O. 012, -0. 176, P 〉 0.05 ） and blood Hcy and carotid artery IMT were significantly positive correlated （ r = 0. 871, O. 819, P 〈 0.01 ）. Conclusion High Cys-C level is an impor- tant risk factor of ACI, and was positively correlated with serum Hcy, and closely related to the formation of CAA.