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Morphological and biochemical properties of synaptic vesicles isolated from guinea pig brain. |
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| Authors: | K Uchizono K Ohsawa H Ikemoto S Al-Samarrai |
| Institution: | Department of Physiology, Faculty of Medicine, University of Tokyo, Tokyo, Japan |
| Abstract: | Two major types of different synaptic vesicles were isolated by centrifugation from the brain homogenate of guinea-pigs. The size and shape of vesicles in each type are different. The one type is spheroid and the other is flattened. The former is larger than the latter. These two types are equivalent to the S-type and F-type vesicles in tissue sample. Sedimentation coefficients of S-type and F-type are 64s and 59s respectively. Amino acid composition of vesicles in each type is almost similar, but the content of amino acids in the S-type is larger than in the F-type except for valine. |
| Keywords: | ACh acetylcholine ATP adenosine 5′-triphosphate EPSP excitatory postsynaptic potential F-type of synapse synapses containing presynaptic flattened vesicles S-type of synapse synapses containing presynaptic spheroidal vesicles GABA γ-aminobutyrate IPSP inhibitory postsynaptic potential |
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