| Effect of the antibody of brain—derived neurotrophic factor on the rat with ischemic injury from obstruction of middle cerebral artery |
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| 引用本文： | 陈英辉,王根发,等.Effect of the antibody of brain—derived neurotrophic factor on the rat with ischemic injury from obstruction of middle cerebral artery[J].中国临床康复,2003,7(1):135-135. |
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| 作者姓名： | 陈英辉 王根发 等 |
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| 作者单位： | [1]DepartmentofNeurology,AffiliatedXinhuaHospitalofSecondMedicalUniversityinShanghai,Shanghai200092,China [2]DepartmentofNeurology,AffiliatedXinhuaHospitalofSecondMedicalUniversityinSh |
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| 摘 要： | AIM：To observe the effect of the antibody of brain-derived neurotrophic factor (BDNF) by cortical microinjection on hippocampal ischemic injury rats.METHODS:Preparation of local cerebral ischemic-reperfusion injury model:cortical stereostaxic approach,microinjection of BDNF antibody.Applied immunohistochemical method to observe distribution of BDNF in cortex after injection of the antibody,to observe the alteration of ischemic injury between control group and BDNF antibody group.RESULT:The volume of cerebral infarction in BDNF antibody group was larger than control group.CONCLUSION:BDNF has protection function for cerebral ischemia.
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| 关 键 词： | 脑缺血 脑源性神经营养因子抗体 大鼠 |
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