| 构建大鼠内囊电毁损痉挛模型 |
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| 引用本文： | 刘鸿燕,周奇志,蔡定均,叶尚志,杨金蓉. 构建大鼠内囊电毁损痉挛模型[J]. 四川生理科学杂志, 2008, 30(2): 61-63 |
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| 作者姓名： | 刘鸿燕 周奇志 蔡定均 叶尚志 杨金蓉 |
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| 作者单位： | 1. 成都中医药大学时间生物医学实验室
2. 成都中医药大学生化实验室,610075 |
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| 摘 要： | 目的：构建一种新的痉挛动物模型以期最大程度地模拟痉挛后的病理生理改变。方法：应用脑立体定位仪，精确地进行深部内囊的损伤定位，采用电毁损内囊的方式制造大鼠痉挛模型。结果：造模后痉挛组大鼠右上肢伸直的幅度与造模前痉挛组、造模前后空白组和假手术组比较明显降低，有统计学意义（P〈0.01）。结论：电毁损内囊可作为大鼠痉挛性瘫痪的一种优选方案。
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| 关 键 词： | 痉挛 内囊 电毁损 大鼠 |
| 修稿时间： | 2008-03-10 |
Establishment of an internal capsule electrolytic damaged spasmodic model in rats |
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| Liu Hong-yan,Zhou Qi-zhi,Cai Ding-jun,Ye Shang-zhi,Yang jin-rong. Establishment of an internal capsule electrolytic damaged spasmodic model in rats[J]. Sichuan Journal of Physiological Sciences, 2008, 30(2): 61-63 |
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| Authors: | Liu Hong-yan Zhou Qi-zhi Cai Ding-jun Ye Shang-zhi Yang jin-rong |
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| Affiliation: | Liu Hong yan, Zhou Qi-zhi, Cai Ding-jun, Ye Shang-zhi, Yang jin-rong (The Chengdu University of TCM, SiChuan Chengdu, 610075) |
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| Abstract: | Objective： To establish a spastic cerebral palsy （SCP） model in order to simulate the changes of pathology and physiology in rats after SCP. Methods：The electrolytic damage of internal capsule for establishment of the rat spastic cerebral palsy model was performed by cerebullar stereotaxic apparatus. Result.st The muscular tension of post-operation palsy group was apparently higher than pre-operation palsy group, pre-operation blank group and sham operation group, post-operation blank group and sham operation group. Conclusion： The electrolytic damage of internal capsule was a good method for establishment of the rat spastic cerebral palsy model. |
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| Keywords: | Spasm Internal capsule Electrolytic damage Rats |
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