| 男性高尿酸血症患者血浆代谢组学的研究 |
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| 引用本文： | 钟麒,高玉霞,常红,王璇,张美琳,边姗姗,黄国伟.男性高尿酸血症患者血浆代谢组学的研究[J].天津医药,2011,39(8):695-697. |
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| 作者姓名： | 钟麒 高玉霞 常红 王璇 张美琳 边姗姗 黄国伟 |
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| 作者单位： | 1. 天津医科大学公共卫生学院,300070
2. 天津医科大学总医院心内科 |
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| 基金项目： | 天津市应用基础与前沿技术研究计划重点项目，天津医科大学科学基金项目 |
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| 摘 要： | 目的:研究男性高尿酸血症(HUA)患者血浆成分的变化,为探讨HUA病因、HUA与其他代谢综合征(MS)组分的关系提供参考。方法:运用氢核磁共振(1H-NMR)代谢组学方法分析高尿酸血症患者(HUA组,n=5)和同期体检健康者(健康对照组,n=5)血浆中饱和脂肪酸、N-乙酰糖蛋白、极低密度脂蛋白(VLDL)等代谢物的变化,结合主成分分析(PCA)和偏最小二乘判别分析法(PLS),分析2组这些代谢物差异。结果:HUA组较健康对照组的饱和脂肪酸、N-乙酰糖蛋白、VLDL、乳酸、乙醇的水平上升,卵磷脂、谷氨酰胺、葡萄糖的水平下降。结论:HUA患者较健康对照组存在脂类代谢异常、糖酵解加剧、谷氨酰胺水平下降等问题,可能与HUA的发病、病程转归有关。
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| 关 键 词： | 高尿酸血症 磁共振 波谱学 代谢 主成分分析 最小二乘法分析 脂类代谢 |
Plasma Metabonomics Analysis of Male Patients with Hyperuricemia |
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| ZHONG Qi,GAO Yuxia,CHANG Hong,WANG Xuan,ZHANG Meilin,BIAN Shanshan,HUANG Guowei.Plasma Metabonomics Analysis of Male Patients with Hyperuricemia[J].Tianjin Medical Journal,2011,39(8):695-697. |
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| Authors: | ZHONG Qi GAO Yuxia CHANG Hong WANG Xuan ZHANG Meilin BIAN Shanshan HUANG Guowei |
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| Institution: | ZHONG Qi,GAO Yuxia,CHANG Hong,WANG Xuan,ZHANG Meilin,BIAN Shanshan,HUANG Guowei School of Public Health of Tianjin Medical University,Tianjin 300070,China |
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| Abstract: | Objective:To analyse changes of plasma composition in male patients with hyperuricemia(HUA).Methods:The differences of metabolites were observed by NMR-based-metabonomics method between HUA group(n=5)and health group(n=5).The data of metabolin was analyzed by principal components analysis(PCA) and orthogonal signal correction(OSC)-partial least squares(PLS) analysis.Results:Compared with health control,there were higher levels of saturated fatty acid(SFA),N-acetyl-glucoprotein(Nac),very low density lipoprot... |
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| Keywords: | hyperuricemia magnetic resonance spectroscopy metabolism principal component analysis least-squares analysis lipid metabolism |
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