急性颅脑损伤后血清IL-10和IL-18的含量变化及临床意义

目的探讨急性颅脑损伤后血清白细胞介素10（IL-10）和白细胞介素18（IL—18）的含量变化及临床意义。方法采用酶联免疫吸附（ELISA）法测定60例急性颅脑损伤患者伤后1d、3d．7d和10d血清IL-10和IL-18的含量，观察IL—10和IL-18血清含量的变化规律，分析颅脑损伤程度与IL-10和IL-18含量之间的关系。结果IL—10在伤后早期即明显升高，于伤后1d即达到高峰，至10d下降明显，但仍高于对照组（P〈0．05）；IL-18含量在伤后呈逐渐升高趋势，并在10d达到高峰。重型颅脑损伤组在伤后各个时间点的血清IL—10和IL-18含量较轻、中型组明显升高（P〈0．05）。结论急性颅脑损伤后血清IL—10和IL-18含量明显升高，与颅脑损伤程度呈正相关；IL-10和IL-18参与了急性颅脑损伤后的炎性反应过程，在继发性脑损害中起重要作用。

Clinical significance of changes in serum IL-10 and IL-18 contents in patients with acute brain trauma

Objective To investigate the changes in levels of serum IL - 10 and IL - 18 and their clinical significance in patients with acute brain trauma. Methods ELISA was used to measure serum levels of IL - 10 and IL - 18 in 1, 3, 7 and 10 days after injury for observing changes, of serum contents of IL - 10 and IL - 18 . The relationship between severity of brain injury and serum levels of IL - 10 and IL - 18 was analyzed in patients with acute brain trauma. Results The serum level of IL - 10 was significantly elevated at the beginning of trauma and it reached peak on 1st day after trauma, although it was obviously dropped on 10th day, and the serum level of IL - 10 was higher in trauma group than that in normal group （ P 〈 0.05 ）. The serum level of IL- 18 was gradually elevated after injury and reached peak on 10th day. The serum levels of IL - 10 and IL - 18 in patients with severe traumatic brain injury were significantly higher than those of patients with mild and moderate injury（ P 〈 0.05 ） at different time points after brain injury. Conclusion The serum levels of IL - 10 and IL - 18 are significantly elevated in patients with acute brain trauma and they are closely related to the severity of brain trauma. IL - 10 and IL - 18 were involved in pathological process of acute brain trauma and they may play an important role in brain injury secondary to the trauma.