Update on the evaluation of hypersensitivity reactions to betalactams |
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| Authors: | M. Blanca,A. Romano,M. J. Torres,J. Fé rnandez,C. Mayorga,J. Rodriguez,P. Demoly,P. J. Bousquet,H. F. Merk,M. L. Sanz,H. Ott,M. Atanaskovi&# -Markovi&# |
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| Affiliation: | Allergy Service, Carlos Haya Hospital, Malaga, Spain;;Department of Internal Medicine and Geriatrics, UCSC-Allergy Unit, Complesso Integrato Columbus, Rome and IRCCS Oasi Maria S.S., Troina, Italy;;Allergy Section, Department of Clinical Medicine, UMH, Elche, Spain;;Research Laboratory, Carlos Haya Hospital-Fundación IMABIS, Malaga, Spain;;Service of Immune-Allergology, Hospital S. João, E.P.E, Porto, Portugal;;Exploration des allergies et INSERM U454, Hopital Arnaud de Villeneuve, Montpellier Cedex, France;;Department of Dermatology and Allergology, Medical Faculty, Aachen, Germany;;Allergy and Clinical Immunology Department, Navarra University Hospital, Pamplona, Spain;;Department of Allergology and Pulmonology, University Children's Hospital, Belgrade, Serbia |
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| Abstract: | Hypersensitivity reactions to betalactams (BLs) are classified as immediate or nonimmediate. The former usually appear within 1 h of drug-intake and are mediated by specific IgE-antibodies. Nonimmediate reactions are those occurring more than 1 h after drug-intake, and they can be T-cell mediated. The diagnostic evaluation of allergic reactions to BLs has changed over the last 5 years, for several reasons. Major and minor determinants are no longer commercially available for skin testing in many countries. In immediate allergic reactions, the sensitivity of skin testing and immunoassays is decreasing and new in vitro methods, such as the basophil activation test, are gaining importance for diagnosis. For nonimmediate reactions, skin testing appears to be less sensitive than previous results, although more studies need to be carried out in this direction. Nevertheless, the drug provocation test is still necessary for diagnosis. |
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| Keywords: | betalactams diagnosis hypersensitivity immmediate nonimmediate |
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