滋养细胞疾病患者血浆纤维结合蛋白的检测意义

目的 探讨血浆纤维结合蛋白(PFn)与良恶性滋养细胞疾病的相关性.方法 62例恶性滋养细胞疾病患者(绒癌35例,侵蚀性葡萄胎27例),54例良性葡萄胎患者及同年龄组健康献血员100例,进行PFn及人绒毛膜促性腺激素(β-HCG)测定.结果 发现恶性滋养细胞疾病组PFn浓度较良性葡萄胎组及健康对照组极明显降低(P＜0.01);而良性葡萄胎组与健康对照组间无显著性差异.结论 PFn可协助诊断恶性滋养细胞疾病,特别在鉴别诊断良、恶性滋养细胞疾病时有一定意义.PFn尚不能作为判断化疗效果的敏感指标.

The significance of Plasma Fibronectin on Trophoblastic Disease

Objective To study the correlation between plasma fibronectin(PFn) and Trophoblastic disease.Methods PFn of 100 healthy,62 patients with malignant trophoblastic disease(35 with choriocarcinoma,27 with invasive mole) and 54 patients with hydatidiform mole were measured.Results The mean level of PFn of malignant trophoblastic disease was obviously less than the hydatidiform mole and normal control,but there was not markedly different between the hydatidiform mole and normal control.Conclusion pFn is important in diagnoses of malignant trophoblastic diseases and differential diagnoses between malignant trophoblastic disease and benign mole.But it is not a sensitive mark for definition of the therapy effect.