经血宁胶囊醇提物凝血作用的比较研究

目的:研究和比较经血宁胶囊醇提物及水提物的凝血作用。方法:动物随机分成6组,即经血宁醇提物3个剂量组(生药18,9.0,4.5 g·kg-1),经血宁水提物组,云南白药组及空白对照组。测定各组凝血时间(CT),凝血酶时间(TT),凝血酶元时间(PT),活化部分凝血活酶时间(APTT),纤维蛋白原(Fbg),血小板(PLT)等凝血指标。结果:与空白对照组比较,经血宁醇提物能明显缩短CT,TT,PT,APTT,血浆复钙时间(PRT),增加Fbg含量和PLT数量(PO.05或P0.01)。与经血宁水提物比较,经血宁醇提物缩短TT,APTT,PRT的作用优于后者(均P0.05)。结论:经血宁醇提物具有显著的凝血作用,其作用强于经血宁水提物。

Comparative Study on Coagulating Action of Water Extract and Alcohol Extract of Jingxuening Capsule

Objective: To study the coagulating action of both extracts(alcohol extract and water extract)of Jingxuening Capsule(JXNC) to find the differences between them. Method: Laboratory animals were randomly divided into six groups,namely blank control group,Yunnan Baiyao powder(YBP) group,JXNC1(extracted by water)and three dosages groups(containing crude drug 18,9.0,4.5 g ·kg^-1 respectively)of JXNC2(extracted by alcohol).CT,TT,PTT,APTT,Fbg,PLT and PRT of each group were tested after administration by ig for 5 or 6 days. Result: Compared with blank control group,JXNC 2 groups were able to shorten CT,TT,PT,APTT,PRT,and increase the content of Fbg and PLT significantly.Compared with JXNC 1 group,TT,APTT,PRT of JXNC 2 were shorter than that of the former(P<0.05). Conclusion: JXNC 2(alcobol extract) has good action for blood coagulation,and it is better than JXNC 1(water extract).