血清超敏C-反应蛋白与血脂水平的相关性研究

目的探讨超敏C-反应蛋白（hs—CRP）与血脂水平的关系。方法对582例健康体检者进行血清hs—CRP、甘油三脂（Tc）、总胆固醇（TC）、高密度脂蛋白（HDL—C）、低密度脂蛋白（LDL—C）浓度测定。对包括TC／HDL—C在内的各项血脂异常者分组并与血脂正常者结果进行分析。结果各血脂异常组与正常组比较hs—CRP差异均有显著性（P〈0．05）；各血脂异常组之间，hs—CRP差异无显著性（P〉0.10）。hs—CRP与TG、TC、LDL—C、TC／LDL—C水平显著正相关（r分别为0．228、0.255、0.198、0.343，P〈0.01）；与HDL—C水平呈显著负相关（r=-0．201，P〈0、01）。结论血脂异常者与血脂正常者hs—CRP浓度有差别，血脂异常者hs—CRP浓度高于正常者；hs—CRP与血脂有相关性。应用hs—CRP与血脂联合检测，更有助于心血管疾病的早期诊断。

Observation on the relationship between the levels of serum supersensitive C - reaction protein and the level of blood fat

Objective To observe the relationship between levels of high-sensitivity C-reactive protein(hs-CRP)and lipids in healthy adults.Methods A total of 582 healthy adults were enrolled in this study and the serum concentrations of hs-CRP,TG,TC,HDL-C,LDL-C were determined.Results The serum level of hs-CRP in every abnormal lipids group was significantly higher than that in the normal group(P<0.05)and there no significant difference in the concentration of hs-CRP was observed among every abnormal lipids groups(P>0.10).The concentration of hs-CRP was positive correlative with the levels of TG,TC,LDL-C,TC/LDL-C(r=0.228,0.255,0.198,0.343,P<0.01),while negatively correlative with HDL-C(r=-0.201,P<0.01).Conclusion The serum concentrations in the normal lipid group are higher than that in the abnormal groups and the concentration of hs-CRP is associated with the level of lipid.Joint determination of hs-CRP and lipid is helpful for early diagnosis of coronary heart diseases.