| 小剂量甲氨蝶呤治疗银屑病的药动学 |
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| 引用本文： | 王娟,梁健健. 小剂量甲氨蝶呤治疗银屑病的药动学[J]. 中国医院药学杂志, 2004, 24(5): 288-289 |
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| 作者姓名： | 王娟 梁健健 |
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| 作者单位： | 广州市第一人民医院,广东,广州,510180 |
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| 摘 要： | 目的:研究小剂量甲氨蝶呤(MTX)用于治疗银屑病时的药动学特点并计算其参数.方法:9例银屑病患者单次静脉滴注MTX 12.5 mg,静脉滴注时间为60～90 min.于给药后0,0.2,0.5,1,1.5,2.5,4,6,8,10,12,24 h抽取静脉血,采用荧光偏振免疫分析法测定MTX浓度,用3P87软件计算其药动学参数.结果:小剂量单次静脉滴注MTX符合开放性二室动力学模型.结论:本结果可以为临床用药提供参考依据.
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| 关 键 词： | 甲氨蝶呤 药物动力学 银屑病 |
| 文章编号： | 1001-5213(2004)05-0288-02 |
| 修稿时间： | 2003-10-05 |
The pharmacokinetics of small dose of MTX in patients with posriasis |
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| WANG Juan,LIANG Jian-Jian. The pharmacokinetics of small dose of MTX in patients with posriasis[J]. Chinese Journal of Hospital Pharmacy, 2004, 24(5): 288-289 |
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| Authors: | WANG Juan LIANG Jian-Jian |
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| Abstract: | OBJECTIVE To study the pharmacokinetics of small dose of MTX in patients with posriasis and calculate the pharmacokinetic parameters. METHODS After a single intravenous dose ( 12.5 mg) was given to nine patients with psoriasis,the serum samples were withdrawn from 0 to 24 h and the blood drug concentration was assayed by TDx.The pharmacokinetic parameters were calculated with 3P87 program software. RESULTS The pharmacokinetics of small dose of MTX in patients with posriasis conformed to two-compartment open model. CONCLUSION The results can be a reference in clinical application. |
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| Keywords: | methotrexate pharmacokinetics posriasis |
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