Autoantibodies and immunoglobulin allotypes in healthy North American Blacks of different age groups |
| |
Authors: | TH Ockhuizen JP Pandey GMP Galbraith HH Fudenberg CG Hames |
| |
Institution: | 1. Department of Basic and Clinical Immunology and Microbiology, Medical University of South Carolina, Charleston, South Carolina 29425, U.S.A.;1. Evans County Health Department, 2 North Newton Street, Claxton, Georgia 30417 U.S.A. |
| |
Abstract: | A population of 291 healthy North American Black subjects of different ages was studied for immunoglobulin (Ig) allotypes and the prevalence of autoantibodies, to determine possible associations between Ig allotypes and age, autoantibodies and age, and Ig allotypes and autoantibodies. Indirect immunofluorescence was used to detect anti-gastric parietal cell, anti-smooth muscle, anti-thyroid microsomal, anti-nuclear, and anti-mitochondrial antibodies. The sera were typed for the Ig allotypes Gm(1, 2, 3, 5, 6, 13, 14, 17, and 21) and Km(1) with a hemagglutination-inhibition assay. A significant association between advanced age and an increased prevalence of anti-nuclear antibodies was observed in females. There was no significant association between Ig allotypes and the autoantibodies tested. The results suggest that Ig allotypes are not involved in the development of autoantibodies in healthy Blacks. |
| |
Keywords: | Correspondence address: Dr J P Pandey Department of Basic and Clinical Immunology and Microbiology Medical University of South Carolina 171 Ashley Avenue Charleston South Carolina 29425 U S A |
本文献已被 ScienceDirect 等数据库收录! |
|