Tyrphostin AG490 Agent Modestly but Significantly Prevents Onset of Type 1 in NOD Mouse; Implication of Immunologic and Metabolic Effects of a Jak-Stat Pathway Inhibitor |
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| Authors: | Abdoreza Davoodi-Semiromi Azadeh Hassanzadeh Clive H Wasserfall Andrew Droney Mark Atkinson |
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| Institution: | Department of Pharmacotherapy and Translational Research, College of Pharmacy, Gainesville, FL, USA, davoodi_semiromi@yahoo.com. |
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| Abstract: | Previously, we have reported that the Jak-Stat signaling pathway is defective in NOD mice. In this study, prediabetic female NOD mice (4?weeks) were treated by intraperitoneal injection either with AG490 or DMSO three times per week for 4 consecutive weeks, followed by once a week for an additional 6?weeks. The onset of diabetes was attenuated in NOD mice treated with AG490 relative to DMSO treated control mice (p?
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