前列腺癌中甾体激素受体共活化物表达研究 |
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引用本文: | 黄翔,邹建华,廖勇,龚百生. 前列腺癌中甾体激素受体共活化物表达研究[J]. 西部医学, 2009, 21(7): 1139-1140 |
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作者姓名: | 黄翔 邹建华 廖勇 龚百生 |
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作者单位: | 四川省医学科学院,四川省人民医院泌尿外科,四川,成都,810072 |
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摘 要: | 目的探讨甾体激素受体共活化物(AIB1)在前列腺癌(Pca)中的表达及激素依赖性转变过程中的作用。方法采用SABC免疫组化法检测40例前列腺癌症患者中AIB1蛋白在BPH、ADPC及AIPC石蜡切片组织中的表达,应用ImageProPlus4.5图象分析软件测定阳性染色积分光密度(10D)值。结果AIB1阳性表达定位于细胞核和/或细胞质中。在8例BPH、20例ADPC和12例AIPC标本中AIB1均有表达,但各组IOD值元统计学差异(P〉0.05)。结论AIB1不是决定前列腺癌生物学行为和激素依赖性的关键因素。
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关 键 词: | 前列腺癌 AIB1 免疫组化 |
AIB1 expression in prostate cancer |
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Affiliation: | HUANG Xiang,ZHOU Jian-hua, LIAO Yong, et al (Department of Urology, Sichuan Academy of Medical Sciences · Sichuan Provincial Peoples Hospital, Chengdu 610072, China) |
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Abstract: | Objective To investigate the expression of AIB1 in prostate cancer and explore the role of AIB1 in regulating the variation of AR-dependence of prostate cancer. Methods AIB1 expression was examined by immunohistochemical assay. The IOD value was canculated by ImagePro Plus 4.5 analysis software. Results AIB1 protein locolized in plasma and/or nuclear. There was no statistical deference of IOD value between each group (P〉0. 05). Conclusion AIB1 is not a crutial factor determining the biological characteristics and AR dependence of prostate cancer. |
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Keywords: | AIB1 |
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