Tolerance to electroacupuncture and its cross tolerance to morphine |
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Authors: | Han Ji-Sheng Li Si-Jia Tang Jian |
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Institution: | Department of Physiology, Beijing Medical College, Beijing, China |
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Abstract: | Electroacupuncture (EA) applied to both legs of the rat for 30 min (1session) raised the average tail flick latency to 89% above the control level. Repeated electroacupuncture for 6 sessions, with 30 min between successive sessions, resulted in a gradual decline in the hypoalgesic effect. The time-course of the development and disappearance of acupuncture tolerance was studied. A bidirectional cross-tolerance between electroacupuncture and morphine points to the similarity between the underlying mechanisms of electroacupuncture hypoalgesia and morphine analgesia. |
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Keywords: | acupuncture electroacupuncture morphine analgesia morphine tolerance |
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