Methionine enkephalin-induced shaking behavior in rats: Dissociation from brain serotonin mechanisms |
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| Authors: | E.G. Drust R.S. Sloviter J.D. Connor |
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| Affiliation: | Department of Pharmacology, The Milton S. Hershey Medical Center, Pennsylvania State University, College of Medicine, Hershey, PA 17033 U.S.A. |
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| Abstract: | Intracerebroventricular injection of methionine enkephalin (met-enkephalin) caused dosedependent shakes in rats. The role of endogenous 5-hydroxytryptamine (5-HT) in met-enkephalin-induced shakes was investigated since shaking behavior has been associated with activation of 5-HT receptors. Met-enkephalin-induced shakes were not affected significantly by pretreatment with p-chlorophenylalanine, 5,7-dihydroxytryptamine, or methysergide. Naloxone inhibited the shakes caused by met-enkephalin. The results suggest that met-enkephalin elicits shaking behavior by a mechanism independent of central 5-HT. |
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