Pyrazole exacerbates handling-induced convulsions in mice |
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| Authors: | J.C. Crabbe E.R. Young J. Janowsky H. Rigter |
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| Affiliation: | 1. Medical Research Service, Veterans Administration Medical Center, Portland, OR 97201, U.S.A.;2. CNS Pharmacology Department, Organon International BV, Oss, The Netherlands |
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| Abstract: | Severity of handling-induced convulsions was reduced in mice in comparison to the scores on an initial test administered 4 days earlier. Daily injections of pyrazole, an inhibitor of alcohol dehydrogenase, prevented the reduction of convulsions in handled mice and exacerbated convulsions in mice tested for the first time after injection. The effects of pyrazole were dose-related. |
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| Keywords: | convulsions handling induced pyrazole refractory period mice |
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