G-6-PD Tripler: A Unique Variant Associated with Chronic Hemolytic Disease |
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| Authors: | ENGSTROM, PAUL F. BEUTLER, ERNEST |
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| Affiliation: | 1 Department of Medicine, Tripler Army Medical Center, Honolulu, Hawaii, andthe Division of Medicine, City of Hope Medical Center, Duarte, Calif.
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| Abstract: | A 52-year-old Caucasian was hospitalized for recurring jaundice. Laboratorytests established a compensated hemolytic anemia due to partial erythrocyteG-6-PD deficiency. Biochemical characterization of the affected enzyme uncovered a unique variant: G-6-PD Tripler. Its significant properties includemarked thermal instability, an electrophoretic mobility slower than the normalB variant in all systems studied, and slightly increased affinity for the substrate G-6-P. Submitted on February 9, 1970 Revised on February 9, 1970 Accepted on February 17, 1970 |
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