海马参与针刺镇痛的传入途径——HRP逆行传递法研究

<正> 近年来,随着对针刺镇痛原理的深入研究,发现海马在针刺镇痛过程中起一定作用。神经生理学实验证明:刺激大鼠背侧海马可提高针刺镇痛效应,损毁背侧海马电针镇痛效应降低;刺激双侧海马可提高痛反应域,并可加强电针效应。对于海马的传入联系前人曾用溃变方法做了大量工作,近年来segal和阪中等先后用HRP逆行传递法进行了研究,但结果不尽

THE AFFERENT PATHWAY OF THE HIPPOCAMPUS ON PARTICIPATION IN ACUPUNCTURE ANALGESIA A Study of Retrograde Transport Method

The afferent connections of the hippocampus in the rat were examined by means of a retrograde axonal transport method of horseradish peroxi- dase (HEP). During injections of HRP in the dorsal or ventrolateral hi- ppocampus, labeled areas did not show any difference, except for the me- dial septal nucleus. Numerous labelled cells were consistently found in the ipsilateral medial septal nucleus, the diagonal band nucleus, the entorhinal cortex, the posterior hypothalamic nucleus, the supramammillary area, the supraoptic area and, bilaterally, the lateral hypothalamus area. when in- jections were made into the dorsal hippocampus, HRP-labelled cells of the medial septal nucleus were observed in medial aspect, but injections made into the ventrolateral hippocampus, revealed HRP-labelled cells of the me- dial septal nucleus in the lateral aspect. After injection into the hippoca- mpus, the supraoptic area was labelled, as first reported. The many areas above-mentioned have a relations with acupuncture analgesia, it is proba- ble that the hippocampus is one of the centres regulating pain in the cent- ral nervous system. Hippocampal function therefore requires further inve- stigation.