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| 热休克预处理对大鼠烧伤后急性胃黏膜损伤的保护作用 | |
| 引用本文： | 张红艳,吕农华,谢勇,陈江,邵立健,王年云.热休克预处理对大鼠烧伤后急性胃黏膜损伤的保护作用[J].现代消化及介入诊疗,2004,9(1):11-13. |
| 作者姓名： | 张红艳 吕农华 谢勇 陈江 邵立健 王年云 |
| 作者单位： | 1. 330006,江西南昌江西医学院第一附属医院烧伤中心 2. 330006,江西医学院第一附属医院消化科 3. 330006,江西医学院2001级博士研究生 |
| 摘 要： | 目的观察热休克预处理对严重烧伤大鼠胃黏膜的影响。方法热休克预处理诱导热休克蛋白产生,然后制作烧伤大鼠急性胃黏膜损伤模型,进行胃黏膜损伤指数评分。运用免疫组化方法,检测胃黏膜热休克蛋白的表达,并进行图像分析。结果热休克预处理组胃黏膜损伤积分显著低于对照组(P<0.01)。免疫组化分析显示其胃黏膜热休克蛋白表达较对照组明显增强(P<0.01)。结论热休克预处理对烧伤大鼠胃黏膜具有保护作用,其保护机制可能与热休克蛋白诱导表达增强有关。 |
| 关 键 词： | 热休克预处理 大鼠 烧伤 急性胃黏膜损伤 保护作用 并发症 |
| 修稿时间： | 2003年11月17 |
The protective role of heat shock pretreatment on acute gastric mucosal lesions in rats caused by burn |
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| ZHANG Hong-yan,LU Nong-hua,XIE Yong,CHEN Jiang,SHAO Li-jian,WANG Nian-yun.The protective role of heat shock pretreatment on acute gastric mucosal lesions in rats caused by burn[J].Modern Digestion & Intervention,2004,9(1):11-13. | |
| Authors: | ZHANG Hong-yan LU Nong-hua XIE Yong CHEN Jiang SHAO Li-jian WANG Nian-yun |
| Institution: | ZHANG Hong-yan,Lu Nong-hua,XIE Yong,CHEN Jiang,SHAO Li-jian,WANG Nian-yun. Burn Center,The First Affiliated Hospital,Jiangxi Medical College,Nanchang 330006,China, Department of Digestive Diseases,The First Affiliated Hospital,Jiangxi Medical College,Nanchang 330006,China, The Postgraduate Student of 2001,Jiangxi Medical College,Nanchang 330006,China |
| Abstract: | Objective To investigate the effects of heat shock pretreatment on the gastric mucosa in severely burned rats. Methods After heat shock proteins (HSPs) were induced by heat shock pretreatment, burn-induced gastric mucosal lesion model was established according to the protocol of Kitajima. Gastric mu-cosal lesion index (LI) was measured in light microscopy. The expression of HSPs was analyzed with immuno-histochemical method. Results Gastric mucosal lesion indexes in heat shock pretreatment group were significantly lower than that in burn group (P < 0.01). The expression of HSPs of heat shock pretreatment group was higher than that of burn group (P<0.01). Conclusion Heat shock pretreatment is of protective role to acute gastric mucosal lesions in burned rats and the mechanism might be closely related to the enhanced expression of induced HSPs. |
| Keywords: | Burn Heat shock proteins ( HSPs ) Gastric mucosal lesion |
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