Electrophysiological monitoring in a patient with an optic nerve glioma |
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Authors: | Phillip Moradi Anthony G. Robson Geoffrey E. Rose Graham E. Holder |
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Affiliation: | Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK. |
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Abstract: | Purpose To report a case illustrating the value of pattern VEP and pattern ERG (PERG) in monitoring optic nerve gliomata (OG). Case report A 15-year-old girl presented with a 3-year history of frontal headaches and a 5-month history of blurred vision in the right eye. MRI scanning revealed a thickened, right optic nerve extending to the cranial opening of the optic canal, consistent with an optic nerve glioma. Pattern VEP showed a mildly delayed major positive component consistent with optic nerve dysfunction. The PERG N95:P50 ratio was subnormal in keeping with retinal ganglion cell involvement. Visual acuity decreased over the following 2 years and repeat VEP objectively demonstrated marked deterioration in optic nerve function despite neuroradiology showing no significant change in the tumour. Conclusions Pattern VEPs and pattern ERGs can provide early objective evidence of optic nerve/retinal ganglion cell dysfunction in optic nerve gliomata. Serial recordings can objectively demonstrate worsening function in the absence of significant neuroradiological change. |
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Keywords: | MRI Optic nerve glioma VEP |
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