| 肝素类药物防治阿尔采末病的研究进展 |
| |
| 引用本文： | 郝丽娜,赵孝林,吴学新.肝素类药物防治阿尔采末病的研究进展[J].齐鲁药事,2014(11):657-660. |
| |
| 作者姓名： | 郝丽娜 赵孝林 吴学新 |
| |
| 作者单位： | 山东大学齐鲁儿童医院药学部,山东 济南,250022 |
| |
| 摘 要： | 本文分析了阿尔采末病(AD)的病理机制,对肝素类药物神经保护机制的进展进行了综述。阐明了肝素类药物可通过调节IP3受体介导的细胞内钙释放,影响淀粉样蛋白(Aβ)沉积及其毒性、调节tau蛋白的磷酸化状态,保护胆碱能神经元等发挥神经保护作用,从而延缓AD的发生与发展。
|
| 关 键 词： | 肝素 阿尔采末病(AD) 细胞内钙 淀粉样蛋白 tau蛋白 胆碱能神经元 |
ResearcH progress oN tHe effects of HepariNs oN AlzHeimer's disease |
| |
| HAO Li-na,ZHAO Xiao-lin,WU Xue-xin.ResearcH progress oN tHe effects of HepariNs oN AlzHeimer's disease[J].qilu pharmaceutical affairs,2014(11):657-660. |
| |
| Authors: | HAO Li-na ZHAO Xiao-lin WU Xue-xin |
| |
| Institution: | HAO Li-na;ZHAO Xiao-lin;WU Xue-xin;Department of Pharmay,Qilu Children’s Hospital of Shandong University; |
| |
| Abstract: | This paper analyzed the pathological mechanisms of AD,reviewed the progress of the mechanisms of the neu-roprotective effect of heparin and its derivatives,clarified that heparin and its derivatives had neuroprotective effects through regulating IP3Rs-mediated intracellular calcium release,inhibiting Aβdeposition and Aβ-induced toxicity,regulating the tau protein phosphorylation state,and protecting cholinergic neurons,thereby delayed the occurrence and development of AD. |
| |
| Keywords: | Heparin Alzheimer's disease Intracellular calcium Aβ(β - amyloid peptide ) Tau protein Cholinergic neurons |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
