鼻咽癌放射治疗后脑损伤对长期生存病人记忆力减退的影响

目的探讨记忆力检测作为放射性脑损伤早期发现方法的可行性。方法检测142例放射治疗后长期生存的鼻咽癌患者记忆商和记忆五项分测验(指向记忆、联想学习、图像自由回忆、无意义图像再认和人像特征回忆),并设30例健康志愿者作为对照组。结果全组患者记忆商和记忆五项分测验结果均低于对照组,与对照组比较差异有统计学意义(P<0.01)。结论放射治疗后长期生存的鼻咽癌患者记忆力下降与放射性脑损伤有关,初步提示进行记忆力动态评测有助于早期发现鼻咽癌病人的放射性脑损伤,为临床治疗和护理提供依据,直接提高患者的生活质量。

Effects of brain injury on the memory loss in the long - term survivals with nasopharyngeal carcinoma after radiotherapy

Objective To study the post-radiotherapeutic effect on the memory of the patients with nasopharyngeal carcinoma and to explore the feasibility of memory detection as the method for early discovery of radioactive brain injury.Methods Memory test was used to assess 124 long-term survivors with nasopharyngeal carcinoma after radiotherapy,and then produce results of five subtests(directional memory,association tests,picture memory,nonsense picture recognition,figures character recall) and memory quotient(MQ) of patients.Thirty healthy volunteers were matched as the control group.Results The results of five subtests and MQ were significantly lower in patients than those in the normal control group(P<0.01).Conclusion Memory test is a valuable tool to early detect and diagnose serious brain injury in long-term survivors of nasopharyngeal carcinoma after radiotherapy,which is useful for the clinical therapy and nursing,as well as the Elevation for the quality of life of patients.