脑出血后早期凝血功能及血白细胞变化的临床意义

目的：探讨脑出血后早期凝血功能及血白细胞（WBC）变化的临床意义。方法选择我院2013年1月-2014年4月收入急诊ICU的32例脑出血患者作为治疗组，同期30例健康体检者作为对照组。比较2组凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原（FIB）、血小板（PLT）和WBC的水平。结果治疗组APTT和WBC水平明显高于对照组，而PLT水平明显低于对照组（P＜0.05）；PT、TT、FIB 2组间比较无统计学差异（P＞0.05）。结论脑出血患者有早期凝血功能异常，WBC升高提示机体存在应激反应，需要综合判断全面分析并予以动态观察，临床指导意义可能更大。

Clinical significance of early coagulation function and white blood cell changes after cerebral hemorrhage

Objective To investigate the clinical significance of early coagulation function and white blood cell （WBC）changes after cerebral hemorrhage. Methods 32 cases of cerebral hemorrhage patients were selected as treatment group from Janaury 2013 to April 2014 in emergency ICU department of our hospital, and during the same period 30 cases of healthy physical examination persons were selected as control group. The level of prothrombin time（PT）,activated partial thromboplastin time（APTT）,thrombin time（TT）,fibrinogen（FIB）,platelet（PLT）and WBC were measured. The differences of PT,APTT,TT,FIB,PLT and WBC were compared between two groups. Results The levels of APTT and WBC in the treatment group were significantly higher than those in the control group,while the level of PLT was significantly lower than that of the control group （P〈0.05 ）.There were no significant difference in the levels of PT,TTand FIB between two groups （P〉0.05）.Conclusion The cerebral hemorrhage patients have abnormal coagulation function in early stage, and the elevated WBC level suggests the existence of stress reaction, which need comprehensive judgment and analysis. Dynamic observation may be of greater significance in clinical guideline.